(2,6-Dichloropyridin-3-YL)methanamine → S-methyl-N-ethyl-N-(6-fluoro-3-pyridylmethyl)-N'-methylisothiourea

HRID 2187243Notes

Reaction equation

HRID 2187243 reaction equation
Cl[C:2]1C(CN)=CC=C(Cl)N=1.[CH2:11]([N:13]([CH2:18][C:19]1[CH:20]=[N:21][C:22]([F:25])=[CH:23][CH:24]=1)[C:14]([NH:16][CH3:17])=[S:15])[CH3:12].CNC(N(CC)CC1C=NC=CC=1)=S>>[CH3:2][S:15][C:14](=[N:16][CH3:17])[N:13]([CH2:11][CH3:12])[CH2:18][C:19]1[CH:20]=[N:21][C:22]([F:25])=[CH:23][CH:24]=1

Participants

4

Reactant 3

HCID 15477284(2,6-Dichloropyridin-3-YL)methanamineHCID 22450434N-methyl-N'-ethyl-N'-(3-pyridylmethyl)thioureaHCID 22450473N-ethyl-N-(6-fluoro-3-pyridylmethyl)-N'-methylthiourea

Product 1

HCID 22450494S-methyl-N-ethyl-N-(6-fluoro-3-pyridylmethyl)-N'-methylisothiourea

Procedure

The reaction procedure of Example 13 (2) was repeated except that N-ethyl-N-(6-fluoro-3-pyridyl-methyl)-N′-methylthiourea was used in lieu of N-methyl-N′-ethyl-N′-(3-pyridylmethyl)thiourea to give S-methyl-N-ethyl-N-(6-fluoro-3-pyridylmethyl)-N′-methylisothiourea as a pale brown oil.

Sources & evidence

ORD record
ord-2fbd565d831d4a27bd5de2bd9fff4ff0
Source dataset
uspto-grants-2002_06
Patent number
US06407248B1

Reaction notes

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