HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-(Chloromethyl)-5-methylpyridine → 5-benzyloxy-N-(6-isopropylpyridin-3-yl)-N-({1-[(5-methylpyridin-2-yl)methyl)pyrazol-4-yl}methyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-(Chloromethyl)-5-methylpyridine | HCID 588056 | — |
| Edukt | 5-benzyloxy-N-(6-isopropylpyridin-3-yl)-N-[(pyrazol-4-yl)methyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide hydrochloride | HCID 67183027 | — |
| Produkt | 5-benzyloxy-N-(6-isopropylpyridin-3-yl)-N-({1-[(5-methylpyridin-2-yl)methyl)pyrazol-4-yl}methyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide | HCID 59597196 | 80,4% |
Reaktionsschritte
By the reaction and treatment in the same manner as in Example 271 using 5-benzyloxy-N-(6-isopropylpyridin-3-yl)-N-[(pyrazol-4-yl)methyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide hydrochloride (0.78 g) and 2-(chloromethyl)-5-methylpyridine (0.43 g) as starting materials, 5-benzyloxy-N-(6-isopropylpyridin-3-yl)-N-({1-[(5-methylpyridin-2-yl)methyl]pyrazol-4-yl}methyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.71 g) was obtained.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08198454B2 |
| Quelldatensatz | uspto-grants-2012_06 |
| ORD ID | ord-c61bcf37671842fdbf361e11c1e885cb |
| Quellennotiz | uspto-grants-2012_06 |