HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol hydrochloride → 3beta-Hydroxy-4,4-dimethyl-24-(3-pentyl)-5alpha-chola-8,14-dien-24-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol hydrochloride | HCID 21887872 | — |
| Reactant | 3beta-tert-Butyldimethylsilyloxy-4,4-dimethyl-5alpha-chola-8,14-dien-24 oic acid-N-methoxy-N-methyl amide | HCID 87822030 | — |
| Reactant | HCID 178456026 | HCID 178456026 | — |
| Product | 3beta-Hydroxy-4,4-dimethyl-24-(3-pentyl)-5alpha-chola-8,14-dien-24-one | HCID 69413845 | — |
Reaction Steps
3β-tert-Butyldimethylsilyloxy-4,4-dimethyl-5α-chola-8,14-dien-24 oic acid-N-methoxy-N-methyl amide (0.57 g) is reacted with 3-pentylmagnesiumbromide and hydrolysed with ethanol/HCl following the procedure outlined in example 6 to give the title compound (13 mg). 1H-NMR (CDCl3, 300 MHz): δ=5.35 (1H, s); 3.23 (1H, m). MS: Calculated: 454.7. Found: 454.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06407086B2 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-e6bd801a556a46fb844b0f295d264760 |
| Source note | uspto-grants-2002_06 |