HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3beta-Hydroxy-4,4-dimethyl-5alpha-chola-8,14-dien-24-oic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ethanol hydrochloride | HCID 21887872 | — |
| Reactant | 3beta-Tert-butyidimethylsilyloxy-4,4-dimethyl-5alpha-chola-8,14-dien-24 oic acid | HCID 69410795 | — |
| Product | 3beta-Hydroxy-4,4-dimethyl-5alpha-chola-8,14-dien-24-oic acid amide | HCID 69411518 | — |
Reaction Steps
3β-tert-Butyldimethylsilyloxy-4,4-dimethyl-5α-chola-8,14-dien-24 oic acid (1.0 g) is reacted with ammonia and hydrolysed with ethanol/HCl following the procedure outlined in example to give the title compound (147 mg). Melting point: 233-235° C. 1H-NMR (CDCl3, 400 MHz)): δ=5.36 (1H, s); 5.45-5.2 (2H, broad d); 3.25 (1H, m). MS: Calculated: 399.6. Found 399.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06407086B2 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-476e607a21814ae88af4ab30e3298f45 |
| Source note | uspto-grants-2002_06 |