HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-Butylamine → 3beta-Hydroxy-4,4-dimethyl-5alpha-chola-8,14-dien-24-oic acid-N-tert-butylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-Butylamine | HCID 6385 | — |
| Reactant | Ethanol hydrochloride | HCID 21887872 | — |
| Reactant | 3beta-Tert-butyidimethylsilyloxy-4,4-dimethyl-5alpha-chola-8,14-dien-24 oic acid | HCID 69410795 | — |
| Product | 3beta-Hydroxy-4,4-dimethyl-5alpha-chola-8,14-dien-24-oic acid-N-tert-butylamide | HCID 69411524 | — |
Reaction Steps
3β-tert-Butyldimethylsilyloxy-4,4-dimethyl-5α-chola-8,14-dien-24-oic acid (0.50 g) is reacted with tert-butylamine and hydrolysed with HCl/ethanol following the procedure outlined in example 39 to give the title compound (204 mg). Melting point: 171-176° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06407086B2 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-44d91aa7cb7747fe981e092e5915fd8a |
| Source note | uspto-grants-2002_06 |