HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 69413965, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 69411676 | HCID 69411676 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 69413965 | HCID 69413965 | — |
Reaction Steps
3β-tert-Butyldimethylsilyloxy-4,4-dimethyl-5α-chola-8,14-dien-24-ol (100 mg) is methylated with sodium hydride 60% (16 mg) and methyl iodine (0.125 ml) in 1 ml of DMF. The protecting tert-butyldimethylsilyl group is split of by treatment with HCl/ethanol. After aqueous work-up and crystallisation from methanol/water, the title compound (5 mg) is isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06407086B2 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-0a9ad29cf87c4497a5a887e522c1b2a3 |
| Source note | uspto-grants-2002_06 |