Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzyl Chloride | HCID 7503 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | HCID 69410833 | HCID 69410833 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 69410835 | HCID 69410835 | — |
Reaction Steps
3β-Hydroxy-4,4-dimethyl-5α-chola-8,14-dien-24-oic acid (100 mg) is suspended in 5 ml of dry DMF. 811 mg of cesium carbonate and 0.29 ml of benzyl chloride is added and the mixture is stirred at 50° C. overnight. After aqueous work-up, column chromatography and crystallisation from acetone/water 55 mg of the title compound is obtained. Melting point: 118-119° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06407086B2 |
|---|
| Source dataset | uspto-grants-2002_06 |
|---|
| ORD ID | ord-f7981bff83f941a2a139ea143099992a |
|---|
| Source note | uspto-grants-2002_06 |
|---|
