2,6-Lutidine → HCID 15460467, compound

Participants

Reaction Steps

To a dichloromethane (15 ml) solution of compound 3 (260 mg, 502 μmol) obtained in Example 1, and 2,6-lutidine (877 μl, 7.53 mmol), triethylsilyl trifluoromethanesulfonate (1.14 ml, 5.02 mmol) was added with ice cooling in an argon atmosphere, and the mixture was stirred for 1.5 hours at the same temperature. The reaction mixture was concentrated under reduced pressure. The resulting residue was purified by flash column chromatography (5% ethyl acetate/hexane) to give colorless oily compound 4 (327 mg, 76%).

Provenance & Evidence