Diethyl (ethoxymethylene)malonate → 2-[(2-Bromo-5-methoxyphenylamino)methylene]malonic acid diethyl ester

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-amino-4-bromoanisole (1.40 g) and diethyl ethoxymethylene-malonate (1.4 ml) was heated at 100° C. for 4 h. The reaction mixture was cooled and ethanol removed at reduced pressure to give the title compound as a waxy brown solid (2.55 g).

Provenance & Evidence