HRID218738

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16227960

4-(Chloromethyl)-2-ethyl-1,3-thiazole

C6H8ClNS

结构：CC(C)c1ccc(NC(=O)C2CCCc3c(OCc4ccccc4)cccc32)cn1

HCID17854215

未命名化合物

PRODUCTS

生成物

结构：CCc1nc(CN(C(=O)C2CCCc3c(OCc4ccccc4)cccc32)c2ccc(C(C)C)nc2)cs1

HCID59597250

未命名化合物

收率 82.5%

PROCEDURE

实验过程

By the reaction and treatment in the same manner as in Example 132 using 5-benzyloxy-N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (1.20 g) and 4-chloromethyl-2-ethylthiazole (0.49 g) as starting materials, 5-benzyloxy-N-[(2-ethylthiazol-4-yl)methyl]-N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (1.30 g) was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e41264b3d7cd49ed92e14b54f1693cd7
来源数据集: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08198454B2
来源说明: uspto-grants-2012_06

反应 SMILES

[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH2:11][CH2:12][CH2:13][CH:14]2[C:19]([NH:21][C:22]1[CH:23]=[N:24][C:25]([CH:28]([CH3:30])[CH3:29])=[CH:26][CH:27]=1)=[O:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:32][C:33]1[N:34]=[C:35]([CH2:38][CH3:39])[S:36][CH:37]=1>>[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH2:11][CH2:12][CH2:13][CH:14]2[C:19]([N:21]([CH2:32][C:33]1[N:34]=[C:35]([CH2:38][CH3:39])[S:36][CH:37]=1)[C:22]1[CH:23]=[N:24][C:25]([CH:28]([CH3:30])[CH3:29])=[CH:26][CH:27]=1)=[O:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1