HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 5-[5-(4-Aminobutyl)pyridin-2-YL]-N-methylpentanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 5-{5-[4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-pyridin-2-yl}-pentanoic acid ethyl ester | HCID 23581272 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-[5-(4-Aminobutyl)pyridin-2-YL]-N-methylpentanamide | HCID 22082672 | — |
Reaction Steps
A mixture of 11-6 (45 g, 110 mmol) and a saturated solution of methylamine in methanol (300 mL) in a sealed tube was heated at 70° C. for 12 hours. The mixture was cooled and concentrated to an oil. The residue was chromatographed on silica gel (10:10:1:1 EtOAc/EtOH/NH4OH/H2O) to give 11-7 as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06410526B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-629a0c20d3e34dd3825f6793d4ec04f2 |
| Source note | uspto-grants-2002_06 |