Diethyl Malonate → HCID 70094731, compound

Participants

Reaction Steps

The enone 15-3 (5.73 g, 28.4 mmol) was dissolved in TBF (200 mL) and EtOH (80 mL) at room temperature. To this was added diethyl malonate (6.46 mL, 42.5 mmol) and NaOEt (1 mL, 2.8 mmol) and the mixture stirred for 1.5 hours. The solution was partitioned between saturated NaHCO3 solution and EtOAc, washed with water, brine, dried (MgSO4) and concentrated in vacuo. The residue was purified by silica gel chromatography (eluting with EtOAc) to give the diester 15-4 as an oil.

Provenance & Evidence