HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Butanol → 6-Bromo-(4-methoxybenzylamino)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Butanol | HCID 263 | — |
| Reactant | 2,6-Dibromopyridine | HCID 12274 | — |
| Reactant | 4-Methoxybenzylamine | HCID 75452 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 6-Bromo-(4-methoxybenzylamino)pyridine | HCID 23435509 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 2,6-dibromopyridine 16-1 (15 g, 70 mmol), 4-methoxybenzylamine (25 mL, 191 mmol) and butanol (25 mL) was heated at 100° C. for 6 days. After cooling, EtOAc was added, the solids removed by filtration and the solution concentrated in vacuo. Purification of the residue by silica gel chromatography (Hexane:EtOAc 4:1) afforded the title compound 16-2 as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06410526B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-557539c57299493bae34e426a08b01e5 |
| Source note | uspto-grants-2002_06 |