5-[2-(4-Methoxybenzylamino)pyridin-6-yl]pentanoic acid ethyl ester → 5-(2-Aminopyridin-6-yl)pentanoic acid ethyl ester

Participants

Reaction Steps

The ester 16-3 (5.7 g) in TFA (75 mL) was heated at 60° C. for 2 hours then cooled and the excess TFA removed in vacuo. The residue was diluted with water, made basic with NaHCO3 and extracted with ether (3×). After washing the ether layer with saturated NaHCO3 then brine, it was dried (Na2SO4) and concentrated to give a viscous oil. Purification by silica gel chromatography (hexane:EtOAc 3:7) afforded the title compound 16-4 as an oil.

Provenance & Evidence