HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Boc-4-(hydroxymethyl)pyrazole → N-(4-isopropylphenyl)-8-nitro-N-[(pyrazol-4-yl)methyl]chroman-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Boc-4-(hydroxymethyl)pyrazole | HCID 17854147 | — |
| Reactant | N-(4-isopropylphenyl)-8-nitrochroman-4-carboxamide | HCID 17854307 | — |
| Product | N-(4-isopropylphenyl)-8-nitro-N-[(pyrazol-4-yl)methyl]chroman-4-carboxamide | HCID 59597301 | 57.3% |
Reaction Steps
By the reaction and treatment in the same manner as in Example 82 using N-(4-isopropylphenyl)-8-nitrochroman-4-carboxamide (4.1 g) and 1-(tert-butyloxycarbonyl)-4-(hydroxymethyl)pyrazole (2.4 g) as starting materials, N-(4-isopropylphenyl)-8-nitro-N-[(pyrazol-4-yl)methyl]chroman-4-carboxamide (2.9 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08198454B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-f3a99581d5c748b1903c8414afa111c0 |
| Source note | uspto-grants-2012_06 |