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HRID 218748作成日：2026年10月25日

7-Fluoro-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid → N-[(1-ethylpyrazol-4-yl)methyl]-7-fluoro-N-(4-isopropylphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide

https://huagongshe.com/reaction/218748

反応式

関与物質

役割名称HCID仕込み量
反応物7-Fluoro-1,2,3,4-tetrahydronaphthalene-1-carboxylic acidHCID 17854522—
反応物N-((1-Ethyl-1H-pyrazol-4-yl)methyl)-4-isopropylanilineHCID 21957909—
生成物N-[(1-ethylpyrazol-4-yl)methyl]-7-fluoro-N-(4-isopropylphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamideHCID 5959722637.5%

反応手順

By the reaction and treatment in the same manner as in Example 12 using 7-fluoro-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid (0.41 g) and [(1-ethylpyrazol-4-yl)methyl](4-isopropylphenyl)amine (0.51 g) as starting materials, N-[(1-ethylpyrazol-4-yl)methyl]-7-fluoro-N-(4-isopropylphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.33 g) was obtained.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08198454B2
出典データセットuspto-grants-2012_06
ORD IDord-df3f57b1c5f647ac9a055d0d46ea72a7
出典メモuspto-grants-2012_06