HCID 17854226, compound → HCID 59597423, compound

HRID 218749Notes

Reaction equation

HRID 218749 reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[O:11][CH2:10][CH2:9][CH:8]2[C:13]([OH:15])=O)#[N:2].[CH2:16]([N:18]1[CH:22]=[C:21]([CH2:23][NH:24][C:25]2[CH:30]=[CH:29][C:28]([CH:31]([CH3:33])[CH3:32])=[CH:27][CH:26]=2)[CH:20]=[N:19]1)[CH3:17]>>[C:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[O:11][CH2:10][CH2:9][CH:8]2[C:13]([N:24]([CH2:23][C:21]1[CH:20]=[N:19][N:18]([CH2:16][CH3:17])[CH:22]=1)[C:25]1[CH:30]=[CH:29][C:28]([CH:31]([CH3:32])[CH3:33])=[CH:27][CH:26]=1)=[O:15])#[N:2]

Participants

3

Reactant 2

HCID 17854226HCID 17854226, compoundHCID 21957909N-((1-Ethyl-1H-pyrazol-4-yl)methyl)-4-isopropylaniline

Product 1

HCID 59597423HCID 59597423, compoundYield 81.3%

Procedure

By the reaction and treatment in the same manner as in Example 12 using 8-cyanochroman-4-carboxylic acid (0.7 g) and [(1-ethylpyrazol-4-yl)methyl](4-isopropylphenyl)amine (0.84 g) as starting materials, 8-cyano-N-[(1-ethylpyrazol-4-yl)methyl]-N-(4-isopropylphenyl)chroman-4-carboxamide (1.2 g) was obtained.

Sources & evidence

ORD record
ord-459ffa79c6704b32b1eddb40eee898de
Source dataset
uspto-grants-2012_06
Patent number
US08198454B2

Reaction notes

Loading…