Water → HCID 15376563, compound

Participants

Reaction Steps

A solution of 1.45 g (4.6 mmol) of methyl 4-(2-aminoethyl)-2-tert-butylaminosulfonylbenzoate and 0.71 ml (5.1 mmol) of triethylamine in 10 ml of dichloromethane was added dropwise to an ice-cooled solution of 1.31 g (13.8 mmol) of methyl chloroformate in 20 ml of dichloromethane. After 2 h at room temperature, water was added, the phases were separated, and the aqueous phase was re-extracted twice with dichloromethane. The combined organic extracts were washed with water, dried over Na2SO4 and concentrated in vacuo. This gave 1.4 g (81%) of methyl 2-tert-butylaminosulfonyl-4-[2-(methoxycarbonylamino)ethyl]benzoate as a viscous oil.

Provenance & Evidence