Hydrochloric Acid → HCID 11092271, compound

Participants

Reaction Steps

0.26 ml (1.7 mmol) of DBU was added dropwise to a suspension of 0.54 g (1.7 mmol) of methyl 2-aminosulfonyl-4-[2-(methoxycarbonylamino)ethyl]benzoate and 0.47 g (1.7 mmol) of N-(4,6-dimethoxypyrimidin-2-yl)phenylcarbamate in 15 ml of acetonitrile. After 2 h, the mixture was diluted with water and diethyl ether and acidified with HCl to pH 1-2, and the product precipitated was removed by filtration, washed with water and diethyl ether and dried. Yield: 0.47 g (55.6%) of methyl 2-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonylaminosulfonyl]-4-[2-(methoxycarbonylamino)ethyl]benzoate of m.p.: 165-169° C./decomp.

Provenance & Evidence