Ammonium Chloride → HCID 131723314, compound

Participants

Reaction Steps

4.2 g of (+/−)-cis-9-ethoxy-8-methoxy-6-(4-cyano-phenyl)-1,2,3,4,4a,10b-hexahydrophenanthridine (compound A1), 0.65 g of ammonium chloride and 0.83 g of sodium azide are suspended in 150 ml of abs. dimethylformamide and heated at 120° C. for 24 h. The reaction mixture is partitioned between water and diethyl ether, and the organic phase is dried with sodium sulfate and concentrated. The residue is chromatographed on silica gel using methylene chloride/methanol in the ratio 4/1. After concentration of the corresponding eluate fractions, the title compound is obtained as a solidified oil.

Provenance & Evidence