HCID 18476046, compound → HCID 18476013, compound

Participants

Reaction Steps

A solution of methyl 3-nitro-6-(4-fluorobenzyl)benzoate (10 g, 36.9 mmol) in ethyl acetate (740 ml) was treated with stannous chloride dihydrate (41.6 g, 184.5 mmol). The mixture was refluxed for 17 hours, evaporated to 300 ml and aqueous ammonia (S.G. 0.88) added to pH 10. The resulting suspension filtered, washed with ethyl acetate and evaporated to give a yellow oil which was purified by flash chromatography (ethyl acetate/ iso-hexane: 1/1) to give methyl 3-amino-6-(4-fluorobenzyl)benzoate (7.54 g; 85%)

Provenance & Evidence