1,2-Dichloroethane → HCID 53639334, compound

Participants

Reaction Steps

L-methionine (N-methylpiperidin-4-yl) ester was prepared as follows: A solution of tert-butoxycarbonyl-L-methionine (5 g; 20 mmol), 4-hydroxy-1-methylpiperidine (3.3 g; 20 mmol); DMAP (2.44 g; 20 mmol) and EDC (4.6 g; 2.4 mmol) in dichloromethane (200 ml) was stirred at ambient temperature overnight. The mixture was extracted with dichloromethane. The organic phase was evaporated and purified by flash chromatography, eluting with dichloromethane/ethanol (97/3) to give 1-methylpiperidin-4-yl-2-tert-butoxycarbonylamino-4-methylsulfanylbutyrate. Yield 56%.

Provenance & Evidence