Hydrochloric Acid → HCID 18476067, compound

Participants

Reaction Steps

A mixture of methyl 5-azidomethyl-2-(4-fluorobenzyl)benzoate (3.23 g), 10% palladium on carbon (0.5 g), 1M. ethereal HCl (20 ml) and methanol (100 ml) was stirred under an atmosphere of hydrogen for 6 hours. The catalyst was filtered off and the filtrate was evaporated to dryness. The residue was treated with saturated aqueous sodium bicarbonate (100 ml) and extracted with ethyl acetate. The solution obtained was dried and evaporated to dryness to give methyl 5-aminomethyl-2-(4-fluorobenzyl)benzoate as a colourless gum (2.7 g).

Provenance & Evidence