HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Ethyl 7-bromo-3-hydroxy-2-naphthoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Naphthalenecarboxylic acid, 7-bromo-3-hydroxy- | HCID 74503 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | Ethyl 7-bromo-3-hydroxy-2-naphthoate | HCID 18476207 | 85% |
Reaction Steps
A solution of 81 g (0.3 mol) of 7-bromo-3-hydroxy-2-naphthoic acid in 600 ml dried EtOH and 60 ml conc. sulfuric acid was heated at reflux for 16 hours. The mixture was cooled to room temperature and treated with water (4000 ml) and neutralised with NaHCO3. The solid was separated by filtration and dried in a drying chamber afforded 75.3 g (85%) of the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06410562B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-f978a3687f9544378fc42058e1d9924b |
| Source note | uspto-grants-2002_06 |