Ethanol → HCID 11651488, compound

HRID 2187657Notes

Reaction equation

HRID 2187657 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:11]([OH:13])=[O:12].S(=O)(=O)(O)O.[CH2:19](O)[CH3:20]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:11]([O:13][CH2:19][CH3:20])=[O:12]

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 178402465-Chloro-1H-indole-3-carboxylic acid

Product 1

HCID 11651488HCID 11651488, compound

Procedure

To a suspension of 5.23 g (26.74 mmol) 5-chloro-1H-indole-3-carboxylic acid in 140 ml dry ethanol were added 10 ml concentrated sulfuric acid, and the mixture was heated with reflux for 16 h. It was concentrated under reduced pressure, and the residue was tretaed with ethanol/hexane to give the crystalline title ester, which was filtered and dried in vacuo.

Workup

  1. temperaturethe mixture was heated
  2. temperaturewith reflux for 16 h
  3. concentrationIt was concentrated under reduced pressure

Sources & evidence

ORD record
ord-4171171620ee4dadba51d0f76219828b
Source dataset
uspto-grants-2002_06
Patent number
US06410562B1

Reaction notes

Loading…