HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 1-Benzyl-5-chloro-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 5-Chloroindole | HCID 87110 | — |
| Catalyst | 18-Crown-6 | HCID 28557 | — |
| Product | 1-Benzyl-5-chloro-1H-indole | HCID 18476362 | 60% |
Reaction Steps
3.85 g (30 mmol) 5-chloroindole was treated with 6.84 g (40 mmol) benzylbromide, 1.97 g (30 mmol) potassium hydroxide (85% powdered in mortar) and 0.25 g (1 mmol) 18-crown-6 as described in Synthesis 1979 p. 618, giving 4.35 g (60%) 5-chloro-1-benzyl-1H-indole, yellow oil, MS (Ei 70 eV) m/Z M+241.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06410562B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-c8bb294274f149a486021e2c82c96850 |
| Source note | uspto-grants-2002_06 |