HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → HCID 18476208, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 5-Chloro-2-methylindole | HCID 70636 | — |
| Catalyst | 18-Crown-6 | HCID 28557 | — |
| Product | HCID 18476208 | HCID 18476208 | 42% |
Reaction Steps
4.97 g (30 mmol) 5-chloro-2-methylindole was treated with 6.84 g (40 mmol) benzyl bromide, 1.97 g (30 mmol) potassium hydroxide (85% powdered in mortar) and 0.25 g (1 mmol) 18-crown-6 as described in Synthesis 1979, p. 618 to give 3.22 g (42%) 5-chloro-2-methyl-1-benzyl-1H-indole, mp: 75-76°, MS (Ei 70 eV) m/Z M+255.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06410562B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-d7c771836c3a4d82a4c52e0b6ddaaaaf |
| Source note | uspto-grants-2002_06 |