N-Acetylimidazolidinone → HCID 18476205, compound

HRID 2187664Notes

Reaction equation

HRID 2187664 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([S:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[CH:5]2.C([N:21]1[CH2:25][CH2:24][NH:23][C:22]1=O)(=O)C>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([S:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[C:5]2[C:22]1[NH:23][CH2:24][CH2:25][N:21]=1

Participants

3

Reactant 2

HCID 79350N-AcetylimidazolidinoneHCID 27629645-Chloro-2-(phenylthio)-indole

Product 1

HCID 18476205HCID 18476205, compound

Procedure

Treatment of 5-chloro-2-(phenylthio)-1H-indole (3.8 mmol, 1 g) with N-acetyl-4,5-dihydro-1H-imidazol-2-one as described in Example 89, Step 3 gave 5-chloro-2-phenylthio-3-(4,5-dihydro-1H-imidazol-2-yl)-1H-indole (0.19 g): MS:327M−; m.p.178° C.; yield (13,4%).

Sources & evidence

ORD record
ord-1b4c9aed7beb41de9e38c51b63543b19
Source dataset
uspto-grants-2002_06
Patent number
US06410562B1

Reaction notes

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