Thionyl Chloride → HCID 18476333, compound

HRID 2187667Notes

Reaction equation

HRID 2187667 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[NH:4][C:5]2[C:10]([C:11]=1[C:12](O)=[O:13])=[CH:9][C:8]([C:15]([F:18])([F:17])[F:16])=[CH:7][CH:6]=2.S(Cl)([Cl:23])=O>>[F:1][C:2]([F:20])([F:19])[C:3]1[NH:4][C:5]2[C:10]([C:11]=1[C:12]([Cl:23])=[O:13])=[CH:9][C:8]([C:15]([F:18])([F:17])[F:16])=[CH:7][CH:6]=2

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 17840233HCID 17840233, compound

Product 1

HCID 18476333HCID 18476333, compound

Conditions

Temperature
70 °C

Procedure

A mixture of 500 mg (1.68 mmol) of the indolecarboxylic acid from Step 4 and 20 ml of thionyl chloride was heated for 3 at 70° C. The excess of thionyl chloride was removed under reduced pressure and the remaining crude acid chloride was dissolved in 30 ml of dry dichloromethane. This solution was used in the next step.

Workup

  1. customThe excess of thionyl chloride was removed under reduced pressure
  2. dissolutionthe remaining crude acid chloride was dissolved in 30 ml of dry dichloromethane

Sources & evidence

ORD record
ord-4d058dc91015445e8e9229bb609a49e8
Source dataset
uspto-grants-2002_06
Patent number
US06410562B1

Reaction notes

Loading…