Pyridine → HCID 18476677, compound

Participants

Reaction Conditions

Reaction Steps

6.1 g (60 mmol) of acetic anhydride are added dropwise to a solution of 10.6 g (50 mmol) of 4-hydroxy-3-propyl-biphenyl, 4.3 g (55 mmol) of pyridine and 0.1 g of 4-(N,N-dimethylamino)pyridine, and the mixture is heated at 50 to 60° C. for 2 hours. The reaction solution is left standing overnight at 20° C. and washed with water and dilute hydrochloric acid, and the organic phase is dried and concentrated. 11.4 g (yield: 89.8% of theory) of 4-acetoxy-3-propyl-biphenyl are obtained as a pale oil of log p=4.32 (pH=2.3).

Provenance & Evidence