HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → methyl 1H-indole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 1H-Indole-5-Carboxylic Acid | HCID 74280 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | methyl 1H-indole-5-carboxylate | HCID 2737635 | 79% |
Reaction Steps
A mixture of 5-carboxyindole (16.0 g), sodium hydrogencarbonate (26.68 g), methyl iodide (61.11 g) and N,N-dimethylformamide (30 ml) is stirred at room temperature for 4 days. Water and ethyl acetate are added thereto for liquid-liquid separation. The organic layer is washed with aqueous sodium hydrogencarbonate, dried and concentrated to obtain 5-(methoxycarbonyl)indole (13.74 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06410584B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-dcfc883d524b4b3d843979a45246ca43 |
| Source note | uspto-grants-2002_06 |