HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → (R)-3-amino-1-(4-chlorobenzyl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (R)-1-(4-Chlorobenzyl)pyrrolidin-3-amine dihydrochloride | HCID 53256324 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (R)-3-amino-1-(4-chlorobenzyl)pyrrolidine | HCID 24904911 | 99.4% |
Reaction Steps
A mixture of (R)-3-amino-1-(4-chlorobenzyl)pyrrolidine dihydrochloride (4.54 g, 16.0 mmol), 2 N NaOH solution (80 mL), and ethyl acetate (80 mL) was shaken, the organic layer was separated, and the aqueous layer was extracted with ethyl acetate (80 mL×2). The combined organic layers were dried over anhydrous sodium sulfate, filtered, and evaporated to give free (R)-3 amino-1-(4-chlorobenzyl)pyrrolidine (3.35 g, 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06410566B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-b341a3791bbe4fd6ac265b96157ba430 |
| Source note | uspto-grants-2002_06 |