Piperidine → HCID 18426261, compound

Participants

Reaction Steps

A solution of 4-[{N-(9-fluorenylmethyloxycarbonyl)glycyl}aminomethyl]-1-(4-methylthiobenzyl)piperidine (590 mg) and piperidine (1 mL) in DMF (4 mL) was stirred at room temperature for 2 h. Concentration and column chromatography (SiO2, Et3N:CH3OH:CH2Cl2=1:1:9) afforded 4-{(glycylamino)methyl}-1-(4-methylthiobenzyl)piperidine (365 mg) as a white solid: 1H NMR (CDCl3, 270 MHz) δ 1.25(dd, J=12 Hz, 4.1 Hz, 2 H), 1.34(dd, J=12 Hz, 4.1 Hz, 2 H), 1.51 (br-s, 2 H), 1.66 (d, J=12 Hz, 2 H), 1.77 (d, J=7.3 Hz, 1 H), 1.94 (t, J=9.5 Hz, 2 H), 2.48 (s, 3 H), 2.80 (d, J=12 Hz, 2 H), 3.18 (t, J=6.2 Hz, 2 H), 3.35 (s, 2 H), 3.45 (s, 2 H), 7.18-7.29 (m, 4 H), 7.35 (br-s, 1 H).

Provenance & Evidence