HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2187825Generated: November 2, 2026
Ammonia → 1-(4-Chlorobenzyl)-4-[{(4-isopropylphenylsulfonyl)glycyl}aminomethyl]piperidine
https://huagongshe.com/reaction/2187825
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | 4-(Propan-2-yl)benzene-1-sulfonyl chloride | HCID 2734882 | — |
| Reactant | 1-(4-Chlorobenzyl)-4-((glycylamino)methyl}piperidine | HCID 18426155 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 1-(4-Chlorobenzyl)-4-[{(4-isopropylphenylsulfonyl)glycyl}aminomethyl]piperidine | HCID 18426209 | — |
Reaction Steps
A solution of 1-(4-chlorobenzyl)-4-{(glycylamino)methyl}piperidine (14.8 mg, 0.05 mmol) in CHCl3 (2 mL) was treated with (piperidinomethyl)polystyrene resin (28 mg, 2.8 mmol/g), 4-isopropylbenzenesulfonyl chloride (1.5 equiv.) and stirred at 25° C. for 16 h. (Aminomethyl)polystyrene was added to scavenge the residual sulfonyl chloride and the reaction mixture was stirred at 25° C. for 16 h. Filtration and concentration afforded 1-(4-chlorobenzyl)-4-[{(4-isopropylphenylsulfonyl)glycyl}aminomethyl]piperidine (compound No. 869) (22.1 mg, 92%): The purity was determined by RPLC/MS (86%); ESI/MS m/e 478 (M++H, C24H32ClN3O3 S).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06410566B1 |
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| Source dataset | uspto-grants-2002_06 |
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| ORD ID | ord-ebe13bbc0bf84dd6b4d6c4b8b467b7be |
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| Source note | uspto-grants-2002_06 |
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