HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butylamine → HCID 18475849, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butylamine | HCID 8007 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 1-(4-Cyano-3-fluorobenzyl)-5-imidazolecarboxaldehyde | HCID 11424708 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 18475849 | HCID 18475849 | — |
Reaction Steps
To a solution of the product from Step G (114 mg, 0.498 mmol) in 1 mL of methanol was added n-butylamine (0.059 mL, 0.60 mmol). After 18 hours, sodium borohydride was added (25 mg, 0.66 mmol) and the reaction was stirred for one hour. The solution was poured into EtOAc, washed with water and brine, dried (Na2SO4), filtered, and concentrated in vacuo to provide the titled product as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06410534B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-278ee3b7586c4deb818893e93c9b819b |
| Source note | uspto-grants-2002_06 |