HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → HCID 18475877, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 3-Aminophenol | HCID 11568 | — |
| Reactant | 2,4-Dimethoxybenzaldehyde | HCID 69175 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 18475877 | HCID 18475877 | — |
Reaction Steps
To a solution of 3-hydroxyaniline (1 equiv) in 1,2-dichloroethane is added 4Å powdered molecular sieves, followed by sodium triacetoxyborohydride (1.5 equiv). 2,4-dimethoxybenzaldehyde (1.1 equiv) is added, and the reaction is stirred at room temperature. After completion, the reaction is poured into EtOAc, washed with sat. aq. NaHCO3 and brine, dried (Na2SO4), filtered, and concentrated in vacuo to provide the titled product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06410534B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-743bafe5c2f04035b28c78708d957b4c |
| Source note | uspto-grants-2002_06 |