Diethylene Glycol Monomethyl Ether → HCID 16679082, compound

HRID 218790Notes

Reaction equation

HRID 218790 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][CH2:7]O.[CH2:9]([O:16][C:17]1[CH:26]=[CH:25][CH:24]=[C:23]2[C:18]=1[CH2:19][CH2:20][CH2:21][CH:22]2[C:27]([N:29]([C:36]1[CH:37]=[N:38][C:39]([CH:42]([CH3:44])[CH3:43])=[CH:40][CH:41]=1)[CH2:30][C:31]1[CH:32]=[N:33][NH:34][CH:35]=1)=[O:28])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[CH2:9]([O:16][C:17]1[CH:26]=[CH:25][CH:24]=[C:23]2[C:18]=1[CH2:19][CH2:20][CH2:21][CH:22]2[C:27]([N:29]([C:36]1[CH:37]=[N:38][C:39]([CH:42]([CH3:44])[CH3:43])=[CH:40][CH:41]=1)[CH2:30][C:31]1[CH:32]=[N:33][N:34]([CH2:7][CH2:6][O:5][CH2:4][CH2:3][O:2][CH3:1])[CH:35]=1)=[O:28])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 8134Diethylene Glycol Monomethyl EtherHCID 595974325-benzyloxy-N-(6-isopropylpyridin-3-yl)-N-[(pyrazol-4-yl)methyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide

Product 1

HCID 16679082HCID 16679082, compound

Procedure

By the reaction and treatment in the same manner as in Example 394 using diethylene glycol monomethyl ether (1 mL) and 5-benzyloxy-N-(6-isopropylpyridin-3-yl)-N-[(pyrazol-4-yl)methyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide (1.0 g) as starting materials, 5-benzyloxy-N-(6-isopropylpyridin-3-yl)-N-({1-[2-(2-methoxyethoxy)ethyl]pyrazol-4-yl}methyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.76 g) was obtained.

Sources & evidence

ORD record
ord-b635543d76244e5cb34d364712b23eb3
Source dataset
uspto-grants-2012_06
Patent number
US08198454B2

Reaction notes

Loading…