HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N,N',N'-Tetramethylazodicarboxamide → Benzyl (3R)-3-t-butoxycarbonylamino-4-(5-cyano-2-iodophenoxy)butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N,N',N'-Tetramethylazodicarboxamide | HCID 4278 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 3-Hydroxy-4-iodobenzonitrile | HCID 10944681 | — |
| Reactant | Boc-D-aspartinol 4-Benzyl Ester | HCID 11045079 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Benzyl (3R)-3-t-butoxycarbonylamino-4-(5-cyano-2-iodophenoxy)butanoate | HCID 11731204 | — |
Reaction Steps
10.16 g (32.8 mmol) of benzyl (3R)-3-t-butoxycarbonylamino-4-hydroxybutanoate was dissolved in 100 ml of toluene. 10.5 g (42.7 mmol) of 3-hydroxy-4-iodobenzonitrile, 11.2 g (42.7 mmol) of triphenylphosphine and 7.4 g (42.7 mmol) of N,N,N′,N′-tetramethylazodicarboxamide were added to the obtained solution under cooling with ice, and they were stirred at room temperature overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06410538B2 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-e8d64426001747bc96b7f5b95a78b568 |
| Source note | uspto-grants-2002_06 |