4-Chlorobiphenyl → 4'-Chloro[1,1'-biphenyl]-4-sulfonic acid

Participants

Reaction Steps

A solution of 4-chlorophenylbenzene (7.02 g, 37.2 mmol) in 70 mL of dichloromethane is treated with chlorosulfonic acid (4.55 g, 39.1 mmol) at RT. The reaction is stirred for 2 h further, and the formed precipitate is collected by vacuum filtration, washed with dichloromethane and dried to afford 9.6 g (96%) of 4′-chlorobiphenyl-4-sulfonic acid as a white solid.

Provenance & Evidence