反应详情

A mixture of methyl cis-3-azidomethylcyclopentancarboxylate (1.2 g, 6.5 mmol) and 1 N sodium hydroxide (12.0 mL, 12 mmol) was stirred at room temperature for about 8 h. The alkaline mixture was extracted with chloroform. The aqueous layer was acidified with hydrochloric acid and extracted twice with chloroform. Combined chloroform extracts from the acidic mixture were dried over sodium sulfate, filtered and concentrated to give about 1.0 g (91%) of cis-3-azidomethylcyclopentancarboxylic acid.

1. extractionThe alkaline mixture was extracted with chloroform
2. extractionextracted twice with chloroform
3. dry with materialCombined chloroform extracts from the acidic mixture were dried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated