反应详情

温度

70 °C

To a mixture of cis-3-aminomethylcyclopentancarboxylic acid (0.2 g, 1.4 mmol) in pyridine (about 5 mL) was added acetic anhydride (about 1 mL) and the mixture stirred at about 70° C. for about 2 h. The solvent was removed under reduced pressure, water was added several times and evaporated in vacuo. A light, viscous oil was obtained and dried in vacuo over acetone reflux to give 0.25 g (97%) of cis-3-[(methylcarbonylamino)methyl]cyclopentancarboxylic acid.

1. customThe solvent was removed under reduced pressure, water
2. additionwas added several times
3. customevaporated in vacuo
4. customA light, viscous oil was obtained
5. dry with materialdried in vacuo over acetone
6. temperaturereflux