HRID218803

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8177

2-(2-Butoxyethoxy)ethanol

C8H18O3

结构：CC(C)c1ccc(N(Cc2cn[nH]c2)C(=O)C2CCCc3c(OCc4ccccc4)cccc32)cn1

HCID59597432

未命名化合物

PRODUCTS

生成物

结构：CCCCOCCOCCn1cc(CN(C(=O)C2CCCc3c(OCc4ccccc4)cccc32)c2ccc(C(C)C)nc2)cn1

HCID17854194

未命名化合物

PROCEDURE

实验过程

By the reaction and treatment of diethylene glycol monobutyl ether (1.0 mL) and 5-benzyloxy-N-(6-isopropylpyridin-3-yl)-N-[(pyrazol-4-yl)methyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.96 g) in the same manner as in Example 394, 5-benzyloxy-N-({1-[2-(2-butoxyethoxy)ethyl]pyrazol-4-yl}methyl)-N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (1.94 g) was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f1fcd5f020cd4f41be0398840cf2df53
来源数据集: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08198454B2
来源说明: uspto-grants-2012_06

反应 SMILES

[CH2:1]([O:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10]O)[CH2:2][CH2:3][CH3:4].[CH2:12]([O:19][C:20]1[CH:29]=[CH:28][CH:27]=[C:26]2[C:21]=1[CH2:22][CH2:23][CH2:24][CH:25]2[C:30]([N:32]([C:39]1[CH:40]=[N:41][C:42]([CH:45]([CH3:47])[CH3:46])=[CH:43][CH:44]=1)[CH2:33][C:34]1[CH:35]=[N:36][NH:37][CH:38]=1)=[O:31])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:12]([O:19][C:20]1[CH:29]=[CH:28][CH:27]=[C:26]2[C:21]=1[CH2:22][CH2:23][CH2:24][CH:25]2[C:30]([N:32]([CH2:33][C:34]1[CH:35]=[N:36][N:37]([CH2:10][CH2:9][O:8][CH2:7][CH2:6][O:5][CH2:1][CH2:2][CH2:3][CH3:4])[CH:38]=1)[C:39]1[CH:40]=[N:41][C:42]([CH:45]([CH3:47])[CH3:46])=[CH:43][CH:44]=1)=[O:31])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1