Diethylene Glycol Monoethyl Ether → HCID 59597284, compound

HRID 218804Notes

Reaction equation

HRID 218804 reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][O:6][CH2:7][CH2:8]O)[CH3:2].[CH2:10]([O:17][C:18]1[CH:27]=[CH:26][CH:25]=[C:24]2[C:19]=1[CH2:20][CH2:21][CH2:22][CH:23]2[C:28]([N:30]([C:37]1[CH:38]=[N:39][C:40]([CH:43]([CH3:45])[CH3:44])=[CH:41][CH:42]=1)[CH2:31][C:32]1[CH:33]=[N:34][NH:35][CH:36]=1)=[O:29])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[CH2:10]([O:17][C:18]1[CH:27]=[CH:26][CH:25]=[C:24]2[C:19]=1[CH2:20][CH2:21][CH2:22][CH:23]2[C:28]([N:30]([CH2:31][C:32]1[CH:33]=[N:34][N:35]([CH2:8][CH2:7][O:6][CH2:5][CH2:4][O:3][CH2:1][CH3:2])[CH:36]=1)[C:37]1[CH:38]=[N:39][C:40]([CH:43]([CH3:45])[CH3:44])=[CH:41][CH:42]=1)=[O:29])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 8146Diethylene Glycol Monoethyl EtherHCID 595974325-benzyloxy-N-(6-isopropylpyridin-3-yl)-N-[(pyrazol-4-yl)methyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide

Product 1

HCID 59597284HCID 59597284, compound

Procedure

By the reaction and treatment of diethylene glycol monoethyl ether (1.5 mL) and 5-benzyloxy-N-(6-isopropylpyridin-3-yl)-N-[(pyrazol-4-yl)methyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.72 g) in the same manner as in Example 394, 5-benzyloxy-N-({1-[2-(2-ethoxyethoxy)ethyl]pyrazol-4-yl}methyl)-N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.89 g) was obtained.

Sources & evidence

ORD record
ord-45cae3faeb064b3783805e6b758e8dec
Source dataset
uspto-grants-2012_06
Patent number
US08198454B2

Reaction notes

Loading…