Azobisisobutyronitrile → D-Glucosamine

Participants

Reaction Steps

Acrylamide (400mg, 5.6 mmole) was dissolved in 10 ml of dimethylsulfoxide(DMSO). To that solution was added 400 mg (1.48 mmole) of N-acryloylglucosamine (Compound VI). Additionally were added 34 mg of N-(2-mercaptoethyl)-2,6-bis(4-benzoylbenzamido)hexanamide, 200 mg of AIBN and 50 μl of TEMED. The solution was sparged with nitrogen, then placed in a 55° C. oven overnight. The resulting polymer solution was dialyzed against deionized water using SpectraPor 1 (Spectrum) dialysis membrane. After dialysis, the solution was lyophilized. The dried polymer obtained was 0.58 gm by weight. At 0.1 mg/ml in deionized water, the polymer had an absorbance at 265 nm of 0.202.

Provenance & Evidence