6-(chloromethyl)-N,N-dimethylpyridin-2-amine → 5-benzyloxy-N-({1-[(6-(dimethylamino)pyridin-2-yl)methyl]pyrazol-4-yl}methyl)-N-(6-methoxypyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide

Participants

Reaction Steps

By the reaction and treatment in the same manner as in Example 271 using 5-benzyloxy-N-(6-methoxypyridin-3-yl)-N-[(pyrazol-4-yl)methyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.94 g) and 6-chloromethyl-2-(dimethylamino)pyridine (0.68 g) as starting materials, 5-benzyloxy-N-({1-[(6-(dimethylamino)pyridin-2-yl)methyl]pyrazol-4-yl}methyl)-N-(6-methoxypyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.31 g) was obtained. 1H-NMR (CDCl3) δ: 1.38-1.67(1H,m), 1.73-2.07(3H,m), 2.61-2.82(2H,m), 3.04(6H,s), 3.59-3.72(1H,m), 3.93(3H,s), 4.64(1H,d,J=14.4 Hz), 4.83(1H,d,J=14.4 Hz), 5.03(2H,s), 5.21(2H,s), 6.18(1H,d,J=7.2 Hz), 6.40(1H,d,J=8.4 Hz), 6.54(1H,d,J=7.5 Hz), 6.62-6.76(2H,m), 7.01(1H,t,J=8.0 Hz), 7.21-7.52(9H,m), 7.99(1H,d,J=2.4 Hz).

Provenance & Evidence