HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloromethyl Methyl Ether → HCID 19932989, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloromethyl Methyl Ether | HCID 7864 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | tert-butyl 4-{2-[(tert-butoxycarbonyl)amino]ethyl}-1H-imidazole-1-carboxylate | HCID 819122 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 19932989 | HCID 19932989 | 84.9% |
Reaction Steps
1-t-Butoxycarbonyl-4-[2-(t-butoxycarbonylamino)ethyl]imidazole (78.1 g) is dissolved in acetonitrile (500 ml), and thereto is added methoxymethyl chloride (22.2 g). The mixture is stirred at room temperature overnight, and poured into aqueous 10% sodium carbonate solution, and extracted with ethyl acetate. The extract is washed, dried and evaporated to give 5-[2-(t-butoxycarbonylamino)ethyl]1-methoxymethylimidazole (54.4 g) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05424316 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-c3008c843851484088435efbc7278fab |
| Source note | uspto-grants-1995_06 |