HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → HCID 18630389, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 18630300 | HCID 18630300 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 18630389 | HCID 18630389 | — |
Reaction Steps
A solution of the compound of Example 263 (0.4 g) and 1 mL thionyl chloride in 6 mL CH2Cl2 was refluxed for 1 h, then cooled and poured into ice-water. Additional CH2Cl2 was added. The organic layer was separated, washed with brine, dried and concentrated. Flash chromatography of the residue with 5% ethyl acetate-hexane as eluent gave 0.4 g of the desired product as a white solid. m.p. 68-72° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06410558B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-93af9a04d0694f15bb51f2efc19d3f70 |
| Source note | uspto-grants-2002_06 |