HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Methylhydrazine | HCID 6061 | — |
| Reactant | 2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester | HCID 78943 | — |
| Product | Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate | HCID 271299 | 75.4% |
Reaction Steps
A solution of ethyl (ethoxymethylene)cyanoacetate (68 g, 0.4 mol) and methylhydrazine (18.5 g, 0.4 mol) in 200 mL absolute ethanol was refluxed for 1.5 h, then cooled to RT and filtered. The filtrate was concentrated in vacuo and the residue was triturated with ether to give 54 g of crude ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate in 75.4% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06410558B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-594873dc046d4e0db0dbfd285c6e3a5a |
| Source note | uspto-grants-2002_06 |