Hydrochloric Acid → HCID 22447523, compound

Participants

Reaction Steps

Raney Nickel (0.7 g) was added to a solution of the above isomer mixture (35.85 g) in ethanol in a hydrogenation reactor at 50° C. under hydrogen at 5 bar for 5 hours. The mixture was cooled, filtered and evaporated to give a 95/5 mixture of 2-chloro-4-trifluoromethylaniline and 2-chloro-5-trifluoromethylaniline (33.1 g). Hydrogen chloride gas was added over 0.5 hour to a solution of the above mixture in ethanol and chlorobenzene, cooled to 0° C., and filtered to give 2-chloro-4-trifluoromethylaniline hydrochloride (33.5 g), having a purity of >99%. The overall yield from 3,4-dichlorobenzotrifluoride was 85%.

Provenance & Evidence