(2S)-(-)-1-Amino-3-phenoxy-2-propanol → HCID 178483522, compound

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The title compound was prepared from 1-{4-[2-(3-dimethylamino-propylamino)-4-oxo-4H-thiazol-5-ylidenemethyl]-phenyl}-piperidin-4-one (which was obtained in Intermediate 33) and (2S)-1-amino-3-phenoxy-propan-2-ol (which was obtained in Intermediate 3) according to the procedure of Example 1 as a yellowish solid; mp 166-168° C. (dec.); 1H NMR (300 MHz, DMSO-d6) δ1.20-1.40 (m, 10 H), 1.60-1.80 (m, 2 H), 1.80-2.00 (m, 2 H), 2.19 (s, 6 H), 2.25 (t, J=6.8 Hz, 2 H), 2.55-3.00(m, 5 H), 3.50-4.05(m, 7 H), 6.65-6.95(m, 3 H), 7.02 (d, J=9.0 Hz, 2 H), 7.20-7.30 (m, 2 H), 7.40 (d, J=9.0 Hz, 2 H), 7.48 (s, 1 H); MS (ES) m/z: 269.6 (M+2H)2+, 100%), 538.1(MH+, 10%); HRMS Calcd. for C29H40N5O3S (MH): 538.2852. Found 538.2885.

Provenance & Evidence